Anaphylaxis Resources

For patients with alpha-gal syndrome (AGS)

Epinephrine is the only effective treatment for anaphylaxis

There is no substitute for epinephrine, which is the only first-line treatment for anaphylaxis. Neither antihistamines nor glucocorticoids work as quickly as epinephrine, and neither can effectively treat the severe symptoms associated with anaphylaxis.

However, antihistamines such as diphenhydramine (Benadryl) or cetirizine (Zyrtec), glucocorticoids like prednisone, or a combination, may be used in addition to epinephrine in some cases of anaphylaxis, after epinephrine is administered.

Kothari P. Epinephrine is the only effective treatment for anaphylaxis. Harvard Health. Published July 9, 2020. Accessed January 4, 2025.

Symptoms of
Alpha-gal Syndrome (AGS)

Alpha-gal reactions usually occur 2-6 hours after people eat foods containing alpha-gal. Some non-food exposures⏤for example, some intravenous drugs⏤ can cause immediate reactions. Note that people with AGS often do not react after every exposure.

Symptoms can range from a mild, itchy rash to life-threatening anaphylaxis. Some people with AGS only have GI symptoms, such as diarrhea or abdominal pain. Others only have joint pain.

It is important to learn how to recognize and respond to the full range of allergic symptoms, especially anaphylaxis.

Learn more about the symptoms of alpha-gal syndromehere.

Anaphylaxis 101

Epi-first, epi-fast!

FARE Food Allergy & Anaphylaxis Care Plan

Use FARE’s downloadable, Food Allergy and Anaphylaxis Care Plan to outline management recommendations in an easy-to-follow format.

Recognizing and Responding to Anaphylaxis

Understanding anaphylaxis can help save a life. Take this free FARE course and encourage your loved ones to as well.  It only takes a few minutes. 

More FARE Anaphylaxis Resources

Epinephrine autoinjectors

All About Epinephrine: What It Does in a Reaction, How Long It Lasts, When It Gets Hot or Cold

From Allergic Living

Are You Using Your Auto-Injector or Inhaler Correctly?

From Allergic Living

“…research reveals that a majority of patients are not using these life-saving devices properly.”

Guide to Emergency Epinephrine Options in the US

From SnackSafely. Includes usage videos and savings programs.

What to Do If You Can’t Afford Epinephrine Auto-Injectors

Can’t afford an epinephrine autoinjector? Advice from the Allergy and Asthma Foundation of America.

How to Use

epinephrine autoinjectors

Dr. Julie Brown fires

4 U.S. brands of

epinephrine autoinjectors

into ballistic gelatin

to highlight their differences.

 

 

 

How to Use an Epipen

How to Use an Auvi-Q

How to Use Amneal's Generic Autoinjector

Neffy
epinephrine nasal spray

Neffy is a needle-free, epineprhine nasal spray.

Neffy Patient Brochure

Downloadable PDF

From ARS Pharma

How to Use Neffy

From ARS Pharma

Neffy Epi Sprayers Now Available in U.S. Pharmacies and Online

From Allergic Living

New Epinephrine Spray

Everything we need to know about the first FDA approved epinephrine nasal spray.

Speaker: Jay Lieberman, MD
From: AAAAI

How to use neffy® (epinephrine nasal spray) in an adult

How to use neffy® (epinephrine nasal spray) in an adolescent

Epi First, Epi Fast: Into the Thigh or Spray in the Nose… how do I choose from all of those?

  • Overview of food allergy and anaphylaxis management
  • Use of omalizumab/anti-IgE in food allergy
  • Review new Anaphylaxis Practice Parameters, including the management of anaphylaxis at home and when to activate EMS
  • Nasal epinephrine

November 12, 2024
Speaker: Dr. Thomas Casale

Are you ready to take the AAAAI Anaphylaxis Quiz?