Pediatrics

Pediatric alpha-gal syndrome (AGS)

A significant number of pediatric cases of AGS has been reported and children represent approximately 12% of subjects in one published cohort. Although published data suggest that the condition in children has similar features to those of adult patients, it is not unusual for children with AGS to report a specific association with limited number of foods, predominance of GI symptoms and particular relevance of activity (e.g., sports practice). 

Commins SP. Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients. Expert Rev Clin Immunol. 2020;16(7):667-677. doi:10.1080/1744666X.2020.1782745

Highlights from

Alpha-gal syndrome in a pediatric patient from northeast Florida. 

Rahalkar NJ, Sanders MR, Joshi SN, Dorman SM, Katz HT.

March, 2026

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The following are excerpts were taken directly from this paper:

Key points

“While larger pediatric cohort studies describing AGS have been reported, they do not provide individual patient-level detail as compared to case reports. We reviewed five case reports detailing individual pediatric cases of AGS.

“Of the reviewed case reports, four out of the five were male pediatric patients, and the average age was seven and a half . It is worth noting that all cases were relatively consistent in age, occurring in young children (under 10).”

“The reported mammalian meat trigger of the described patients was also reported more commonly as beef or pork when specified. Similarly, our case of a 10-year-old male patient identified beef as his primary trigger. “

Key Publications

Key papers pediatric alpha-gal syndrome

See also more general papers on diagnosis and management or alpha-gal syndrome.